Adults taking high doses of amphetamine-based medications for ADHD, such as Adderall, face a five-fold increased risk of developing psychosis or mania. The risk was highest for those taking 30 mg or more of dextroamphetamine, with 81% of psychosis or mania cases potentially avoidable by lowering the dose.

New research reveals that cognitive impairments in psychotic disorders, like schizophrenia and bipolar disorder, are connected to brain network organization. This connection is evident even before the first psychotic break in at-risk individuals, offering potential for early diagnosis and intervention. The study highlights a novel brain network-cognition relationship that could lead to targeted treatments for these often treatment-resistant symptoms.

Individuals with the 22q11.2DS genetic deletion show unique patterns of brain activity and structure, which could predict their risk of psychosis. By studying brain "coupling" from childhood to adulthood, scientists discovered discrepancies in brain regions linked to schizophrenia.