Researchers have developed a potential diagnostic tool for schizophrenia by observing how patients process conflicting information. By analyzing neural activity between the cortex and thalamus, they found distinct patterns that make schizophrenia patients more sensitive to uncertainty.

A study has identified mutations arising during brain development that may contribute to schizophrenia. Unlike inherited genes, these somatic mutations occur after conception and were found more frequently in schizophrenia patients' brain tissue. By sequencing DNA from neurons in the dorsolateral prefrontal cortex, researchers identified single-nucleotide variants linked to disrupted brain functions. This discovery highlights the importance of studying both inherited and non-inherited genetic factors.

Researchers have developed the first 3D map of gene regulation in the human brain, offering insights into how early brain development influences lifelong mental health. This map, focusing on regions tied to memory and emotional regulation, reveals how chromatin structure controls gene activity, especially during key developmental stages.

Scientists have identified how genetic variants influence the risk of neurological and psychiatric disorders, including schizophrenia and autism. Using live neural cells and DNA sequencing, researchers discovered thousands of "non-coding" genetic variants with context-dependent functions, activated during brain development.