A new gene therapy has restored vision in patients with Leber congenital amaurosis type I (LCA1), a rare genetic condition causing blindness. In a small trial, those receiving the highest dose saw up to a 10,000-fold improvement in light sensitivity and significant gains in reading and navigation abilities.

The brain builds a hierarchy of knowledge, connecting lower-order sensory details to higher-order concepts, shaping our perception of the world. A new study reveals how visual experience influences the brain’s feedback connections, allowing us to integrate context and recognize patterns based on past experiences. Researchers found that visual input refines these connections, enhancing our ability to interpret complex stimuli and update our understanding of the environment.

Researchers used Game of Thrones to study how the brain recognizes faces, providing insights into prosopagnosia, a condition affecting facial recognition in 1 in 50 people. MRI scans showed increased brain activity in regions associated with character knowledge in fans of the series, but reduced activity in those unfamiliar with the show and in prosopagnosia patients.

New research reveals that individuals who experience vision loss before age 10 struggle more with judging sound distance compared to those who lose sight later in life. This difficulty in perceiving the location of sounds has significant implications for safety and navigation. The study highlights the need for tailored healthcare solutions for those with early vision loss to enhance their quality of life.

Researchers found that daily antioxidant supplements slow the progression of late-stage dry age-related macular degeneration (AMD). The supplements help preserve central vision by slowing the expansion of geographic atrophy regions in the retina. This finding supports the use of AREDS2 supplements for people with late dry AMD.