Fear memories initially form broad associations, but over time, they shift to become episodic memories tied to specific timelines. This process involves the hippocampus early on, with the dorsolateral prefrontal cortex integrating the event sequence later.

Researchers have identified a protein complex, TrkC-PTPσ, that plays a key role in the structural organization of synapses in the brain, impacting cognitive behaviors. By studying this complex, scientists uncovered how it regulates synaptic protein phosphorylation, essential for healthy brain function. Disruptions in this protein complex led to anxiety-like behaviors in mice, providing insights into mental health conditions like anxiety and autism.

A new study reveals that how children mentally process traumatic events is the most significant factor in predicting their mental health outcomes, including PTSD, anxiety, and depression. Cognitive factors—like how children remember the event and view themselves afterward—play a more critical role than the event’s objective severity. Researchers found that children with more negative self-perceptions or distorted memories were at higher risk for long-term psychological impacts.

A new study reveals that inflammation and immune system activation are closely linked to major depressive disorder (MDD), particularly in those resistant to standard antidepressants. Researchers analyzed gene expression in people with depression, finding increased immune-related gene activity, especially in those with higher inflammation.

A recent review highlights the potential of liver X receptor beta (LXRβ) as a target for treating depression and anxiety. Known for regulating cholesterol, LXRβ is emerging as a key player in mental health, with research showing its role in balancing neurotransmission and enhancing cognitive function.