Researchers developed a computer model that mimics how the hippocampus stores new episodic memories without erasing old ones. This model demonstrates that the CA3 region of the hippocampus serves as an anchor point for memories, allowing efficient storage in surrounding regions.

A new study reveals that the epigenetic state of neurons determines their role in memory formation. Neurons with open chromatin states are more likely to be recruited into memory traces, showing higher electrical activity during learning. Researchers demonstrated that manipulating these epigenetic states in mice can enhance or impair learning. This discovery shifts the focus from synaptic plasticity to nuclear processes, offering potential new avenues for treating cognitive disorders.