Researchers uncover how specific brain cells and circuits become vulnerable in Alzheimer's disease and identify factors that may promote resilience to cognitive decline. Analyzing gene expression in over 1.3 million cells across multiple brain regions, the study highlights the role of Reelin in neuron protection and choline metabolism in astrocytes for cognitive resilience. These findings pave the way for potential therapeutic targets to sustain cognition and memory amid Alzheimer’s pathology.