Researchers have discovered that the enzyme ATP-citrate lyase (ACLY) plays a critical role in driving the inflammatory process linked to aging, known as the senescence-associated secretory phenotype (SASP). The study shows that blocking ACLY can reduce the expression of inflammation-related genes in aging cells, opening the door for potential therapies to combat age-related diseases like dementia and atherosclerosis.

New research explores how chronic liver inflammation may lead to brain inflammation and cognitive decline as people age. Through the study of necroptosis, a form of cell death that triggers inflammation, researchers are examining how inflammatory molecules released by the liver impact the brain. Early findings suggest that blocking necroptosis reduces liver and brain inflammation, potentially helping to maintain cognitive function.

New research shows that severe Covid-19 infection can cause inflammation in the brainstem, potentially leading to prolonged symptoms like fatigue, breathlessness, and anxiety. Using ultra-high-resolution 7-Tesla MRI scanners, scientists observed specific brainstem areas associated with these symptoms, highlighting how immune response post-infection might affect brain health.

A new study reveals that inflammation and immune system activation are closely linked to major depressive disorder (MDD), particularly in those resistant to standard antidepressants. Researchers analyzed gene expression in people with depression, finding increased immune-related gene activity, especially in those with higher inflammation.