Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key feature of Alzheimer’s disease and related dementias. By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway.

Astrocytes, non-neuronal brain cells, have been shown to work alongside neurons to store and recall memories, reshaping our understanding of memory mechanisms. Researchers found that specific astrocytes express the c-Fos gene during memory formation, influencing neuron communication to store memories.