A new review highlights how air pollution, particularly fine particles and nitrogen oxides, can elevate autism risk by disrupting critical brain development processes. Key mechanisms, including nitrosative stress, neuroinflammation, and neurotransmitter disruptions, reveal how prenatal and early childhood exposure impact neurological health. Small particles, such as PM2.5, can cross the placenta, potentially harming fetal brain development, especially for genetically predisposed individuals.